What is REVEL?

REVEL is an ensemble method for predicting the pathogenicity of missense variants based on a combination of scores from 13 individual tools:

• MutPred
• FATHMM v2.3
• VEST 3.0
• PolyPhen-2
• SIFT
• PROVEAN
• MutationAssessor
• MutationTaster
• LRT
• GERP++
• SiPhy
• phyloP
• phastCons.

The dataset of REVEL scores was calculated in 2016 and were not updated since then.

How to Use REVEL Scores

REVEL score higher than 0.5 predicts that the variant is likely to cause harmful effect on the protein. The higher the score, the more likely the harmful effect.

Additional Reading

Original paper: "REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants"