What REVEL predicts
REVEL is an ensemble score for rare missense variants. It combines outputs from 13 tools, including SIFT, PolyPhen-2, MutationAssessor, MutationTaster, FATHMM, VEST, PROVEAN, LRT, GERP++, SiPhy, phyloP, phastCons, and MutPred.
Score range
REVEL scores run from 0 to 1. Higher values mean the model predicts a greater chance that the missense variant harms protein function.
Strengths and limits
REVEL is useful when you need a single combined signal from older missense predictors. The published REVEL score set was calculated in 2016, so treat it as a fixed annotation and check it with current population, ClinVar, and case context.